Plantwise Relax and Rest helps calm your mind to sink into a restful sleep with balancing adaptogens, herbs, and amino acids so you can wake up to a revitalized morning.*

As seen on the oil side of the capsule, the whole hemp oil is clean CO2 extracted from regeneratively-grown, organic Futura 75, a European Union DNA-verified, heirloom industrial hemp cultivar. The whole hemp oil is Self-Affirmed GRAS and is independently tested for purity across 300 pesticides and herbicides and is solvent and isolate-free.

Phytocannabinoids, found naturally in hemp, support the most important physiological system that helps modulate all physiological systems in the body – the endocannabinoid system (ECS).*

The ECS influences sleep in multiple locations within the brain and plays a role in circadian components of sleep-wake cycling. Phytocannabinoids help support CB1 receptors (in the ECS) that trigger the release of sleep-inducing molecules, creating a calming effect and supporting REM sleep (our deepest phase of sleep).*

Venetron Rafuma leaf extract has been shown to promote a positive outlook, alleviate occasional stress and improve sleep quality. The mechanism of action for these effects is thought to be related to preventing the breakdown of serotonin (which increases serotonin levels) throughout the day, resulting in increased production of melatonin at night. In addition, Venetron works along with the amino acid GABA and improves its ability to bind to receptors in the brain. By doing so, GABA helps quiet a busy mind, provide a calming effect, and alleviate stress that interferes with sleep.*

GABA is an amino acid naturally produced in the brain that works by quieting an active, busy mind that can interfere with sleep. In doing so, GABA helps to reduce anxiousness and creates a calmness of mood that helps induce restful sleep. Therefore, supplemental GABA benefits sleep by aiding relaxation and providing relief from anxiety and stress that are known to cause occasional sleeplessness. PharmaGABA® is a natural form of GABA produced with the help of the probiotic Lactobacillus hilgardii – a beneficial lactic acid bacteria.*

5-HTP is an amino acid derivative produced from tryptophan, which gets converted to serotonin. Serotonin helps regulate mood and anxiety and has a positive effect on sleep. 5-HTP has been shown to shorten the time to get to sleep and provides for a deeper sleep. In addition, 5-HTP increases serotonin which can be converted to melatonin – the important sleep regulating hormone. When 5-HTP is combined with GABA, the combination supports sleep duration and quality, while helping reduce sleep latency.*

Valerian root extract helps create a relaxing and sleep-supporting effect without inducing unwanted morning grogginess. Components of valerian inhibit the breakdown of GABA in the brain and induce calming relaxation. Additionally, valerian root extract helps reduce sleep latency while supporting sleep quality.*

Melatonin is a hormone that the brain produces that helps with the timing of your circadian rhythm and sleep. Melatonin binds to receptors in the brain to reduce activity and levels of dopamine that help you stay awake. Your body produces melatonin naturally and, as melatonin levels rise in the evening, they let the body know it is nighttime and time for sleep. Numerous scientific and clinical studies have been published which establish melatonin supplementation’s usefulness in significantly reducing both sleep issues and length of time to get to sleep.*