Nutrient Glossary

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5-Hydroxytryptophan (5-HTP) (from Garcinia simplicifolia seed extract) 

5-HTP is an amino acid derivative produced from tryptophan, which gets converted to serotonin. Serotonin helps regulate mood and anxiety and has a positive effect on sleep. 5-HTP has been shown to shorten the time to get to sleep and provides for a deeper sleep. In addition, 5-HTP increases serotonin which can be converted to melatonin – the important sleep regulating hormone. When 5-HTP is combined with GABA, the combination supports sleep duration and quality, while helping reduce sleep latency.*

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Andrographis (Organic) (Andrographis paniculata) leaf extract (standardized Andrographolides) from ParActin®

Important phytonutrients in Andrographis called andrographolides possess antioxidant, and immunostimulant activity. These nutrients play a role in increasing certain immune cell activity and support immune system modulation.*

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Ashwagandha (Organic) (Withania somnifera) root extract (standardized Withanolides) from KSM66®

Ashwagandha increases energy and improves overall health by reducing stress. Stress is a state of mental or emotional strain or tension, which can lead to underperformance. Some studies demonstrate Ashwgandha’s role in improving cognition, attention, memory, focus, concentration, and energy levels without stimulating the nervous system. Improvements in oxygen consumption, strength, and endurance have also been associated with Ashwagandha intake.*

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Astragalus (Astragalus membranaceus) root extract

The active compounds in Astragalus are polysaccharides, which help to protect the immune system and support immune response.*

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Black Cumin Seed (Nigella sativa) oil

Thymoquinone is found in the seeds of Nigella sativa, known as black cumin seed. The different properties of thymoquinone have been traditionally recognized to have antioxidant effects. As a complement to Beta-caryophyllene’s effects on inflammatory cytokines (inflammatory components from the immune system), thymoquinone exerts support by modulating cyclooxygenase enzymes (COX 1 and 2). These enzymes are involved in the production of cytokines.*

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Beta-Caryophyllene 

Standardized from Clove (Syzygium aromaticum) bud oil and Black Pepper (Piper nigrum) berry oil Beta-caryophyllene is a novel phytocannabinoid found in hemp, but it is more abundant in essential oils of various plants, including black pepper and clove. Beta-caryophyllene binds strongly to the cannabinoid receptor in the body, called CB2. The CB2 receptor is expressed abundantly in immune cells and its activation supports the reduction of temporary discomfort from overexertion.*

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Boswellia (Boswellia serrata) extract (gum resin) from 5-LOXIN®

Boswellia serrata has a long history of use and contains phytochemicals that increase the body's immune response. 5-LOXIN is a novel extract from Boswellia serrata standardized for potent, active molecules called boswellic acids. These active molecules exert beneficial properties by inhibiting the 5-lipoxygenase enzyme (an enzyme involved in oxidizing fats and other beneficial compounds in the body). Research using 5-Loxin proved to be beneficial in addressing joint health by inhibiting enzymes that break down cartilage, collagen and connective tissues.*

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Caffeine

Caffeine is a well-known and well-studied mild stimulant of the central nervous system that quickly boosts our alertness and energy levels. Combined with the other ingredients in our formula, the benefits of caffeine shine while minimizing negative effects.* Caffeine is sourced from PurCaf™ organic green coffee (Coffea arabica) bean extract, PurTea® organic green tea (Camellia sinensis) leaf extract, AmaTea® organic guayusa (Ilex guayusa) leaf extract (standardized 40% polysaccharides 80 mg)

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Chamomile (Matricaria recutita) flower extract

This well-known herbal extract has a long history of use and helps relax the body, calm the mind, and help prepare you for a restful sleep.*

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ElevATP®

A combination of ancient peat and apple skin extracts ElevATP® is a natural combination of ancient peat and apple polyphenols demonstrated to increase levels of mitochondrial ATP and support improved strength, power and performance. The mitochondria are the energy producers in all cells and ATP is the currency that they use to produce the energy essential for physical and mental performance. When physical or mental activity is required, more ATP is needed. ElevATP® complements the other ingredients in plantwise mind spark to help sustain adequate ATP in order to support attention, focus and energy levels in the body.*

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European Elderberry (Sambucus nigra) fruit extract (standardized Anthocyanins) 

European elderberry has been used for its health benefits for thousands of years.The relationship between elderberry and immune system health is primarily related to the reduction of oxidative stress from the antioxidants and anthocyanins found in the berries.*

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Ginger (Zingiber officinale) root extract 

Ginger root contains important bioactive components called gingerols that support pain reduction the same way as COX inhibitors. COX inhibitors help repair and promote articular cartilage growth – great for joints! In addition, ginger also contains small amounts of salicylates that can contribute to easing pain and discomfort. Research has demonstrated ginger’s traditional use for several conditions, including delayed onset muscle soreness associated with overexertion.*

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Hemp (VOHO™ Regeneratively-Grown, Organic Whole Hemp Plant Extract)

As seen on the oil side of the dual-capsule formulas, the whole hemp oil extract is a clean, CO2 extraction from regeneratively-grown, organic Futura 75, a European Union DNA-verified, heirloom industrial hemp cultivar. The whole hemp oil is Self-Affirmed GRAS and is independently tested for purity across 300 pesticides and herbicides and is solvent and isolate-free.

Phytocannabinoids found naturally in hemp (such as CBD, CBE and CBG) support the most important physiological system that helps modulate all physiological systems in the body – the endocannabinoid system (ECS).*

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Lemon Balm (Melissa officinalis) leaf extract

This well-known herbal extract has a long history of use and helps relax the body, calm the mind, and help prepare you for a restful sleep.*

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L-Theanine

L-theanine, typically found in green and black tea, is an important amino acid involved in numerous health-promoting processes in the body to improve stress tolerance and toning caffeine's role in stimulation. When paired with caffeine, improvements in focus, attention, reaction times, and task accuracy have been observed. L-theanine and caffeine have repeatedly delivered unique cognitive benefits when consumed in combination. L-theanine can also suppress excitatory activity in the central nervous system to help reduce stimulant jitters from caffeine and allow caffeine to work its brain-boosting effects without allowing it to raise anxiety.*

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Melatonin 

Melatonin is a hormone that the brain produces that helps with the timing of your circadian rhythm and sleep. Melatonin binds to receptors in the brain to reduce activity and levels of dopamine that help you stay awake. Your body produces melatonin naturally and, as melatonin levels rise in the evening, they let the body know it is nighttime and time for sleep. Numerous scientific and clinical studies have been published which establish melatonin supplementation’s usefulness in significantly reducing both sleep issues and length of time to get to sleep.*

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Mushroom Fruiting Bodies (Organic) (standardized beta (1,3) (1,6) glucans) 

Organic Maitake Mushroom (Grifola frondosa) fruiting bodies extract, Organic Reishi Mushroom (Ganoderma lingzhi) fruiting bodies extract, Organic Shiitake Mushroom (Lentinula edodes) fruiting body extract, Organic Turkey Tails Mushroom (Trametes ersicolor) fruiting bodies extract, Organic Chaga (Inonotus obliquus) extract

Beta glucans from mushrooms play a role in activating immune cells to boost their function. They have a remarkable ability to activate and stimulate healthy innate (the first line of defense) and adaptive (the second line of defense) immune response.*

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Passionflower (Passiflora incarnata) flower extract

This well-known herbal extract has a long history of use and helps relax the body, calm the mind, and help prepare you for a restful sleep.*

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PharmaGABA® (gamma-aminobutyric acid)

GABA is an amino acid naturally produced in the brain that works by quieting an active, busy mind that can interfere with sleep. In doing so, GABA helps to reduce anxiousness and creates a calmness of mood that helps induce restful sleep. Therefore, supplemental GABA benefits sleep by aiding relaxation and providing relief from anxiety and stress that are known to cause occasional sleeplessness. PharmaGABA® is a natural form of GABA produced with the help of the probiotic Lactobacillus hilgardii – a beneficial lactic acid bacteria.*

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Rafuma Leaf a trademarked extract of the Rafuma leaf (Apocynum venetum) from Venetron®

Venetron Rafuma leaf extract has been shown to promote a positive outlook, alleviate occasional stress and improve sleep quality. The mechanism of action for these effects is thought to be related to preventing the breakdown of serotonin (which increases serotonin levels) throughout the day, resulting in increased production of melatonin at night. In addition, Venetron works along with the amino acid GABA and improves its ability to bind to receptors in the brain. By doing so, GABA helps quiet a busy mind, provide a calming effect, and alleviate stress that interferes with sleep.*

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Selenium as Selenomethionine 

Selenium plays a critical role in reducing oxidative stress and promoting balance in certain cells involved in innate and adaptive immune responses.*

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Turmeric (Curcuma longa) root extract (standardized Curcuminoids) 

Turmeric has been used for centuries for relief from occasional aches, joint stiffness, and muscle soreness. Curcumin’s major activity is from its active class of compounds called curcuminoids. Like thymoquinone, curcumin’s efficacy is facilitated by its action on the COX enzymes. Like beta-caryophyllene, curcumin also has a modulating effect on cytokines.*

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Valerian (Valeriana officinalis) (standardized valerenic acids) 

Valerian root extract helps create a relaxing and sleep-supporting effect without inducing unwanted morning grogginess. Components of valerian inhibit the breakdown of GABA in the brain and induce calming relaxation. Additionally, valerian root extract helps reduce sleep latency while supporting sleep quality.*

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Vitamin D as Cholecalciferol from Lichen (Caldonia rangiferina) 

Vitamin D boosts the production of immune cells and can modulate the innate and adaptive immune responses.*